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Molecular Recognition of a Peptide by the Nickel(II) Complex of 1,4,7,10-Tetraazacyclododecane-2,9-dione

✍ Scribed by Jian Gao; Joseph H. Reibenspies; Yizhen Sun; Arthur E. Martell

Publisher
John Wiley and Sons
Year
2003
Tongue
German
Weight
99 KB
Volume
86
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The nickel(II) complex of the macrocycle 1,4,7,10‐tetraazacyclododecane‐2,9‐dione (dota) was found to be efficient in the recognition of the dipeptide, glycyl‐glycine (Gly‐Gly) in aqueous solution. This (dota)Ni^II^ complex serves as a targeting molecule to form a stable ternary complex with the dipeptide at pH 8.3 in aqueous solution. The recognition constant (log K=19.20) and the recognition mechanism were investigated based on the potentiometric method. The single‐crystal of a six‐coordinated (dota)~2~Ni^II^ complex is also reported.

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