Molecular recognition mechanisms of thrombin
β Scribed by J. A. HUNTINGTON
- Book ID
- 109149012
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 856 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1538-7933
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π SIMILAR VOLUMES
A new route via intermediate pseudoenantiomers was developed to synthesize racemic and enantiomerically pure new non-peptidic inhibitors of thrombin, a key serine protease in the blood-coagulation cascade. These ligands feature a conformationally rigid tricyclic core and are decorated with substitue
Biomolecular recognition is complex. The balance between the different molecular properties that contribute to molecular recognition, such as shape, electrostatics, dynamics and entropy, varies from case to case. This, along with the extent of experimental characterization, influences the choice of