Structure-Based Design of Nonpeptidic Th
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Patrick Betschmann; Stefan Sahli; François Diederich; Ulrike Obst; Volker Gramli
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Article
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2002
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John Wiley and Sons
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German
β 493 KB
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Structure-activity relationships for new members of a class of nonpeptidic, low-molecular-weight inhibitors of thrombin, a key serine protease in the blood coagulation cascade, are described. These compounds, which originate from X-ray-structure-based design, feature a conformationally rigid, bi-or