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Molecular recognition and modulation of hepatocyte growth factor activity by heparan and dermatan sulfates

✍ Scribed by Krista Catlow; Jon A. Deakin; Maryse Delehedde; David G. Fernig; Mauro S.G. Pavao; John T. Gallagher; Malcolm Lyon

Book ID
110756941
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
276 KB
Volume
85
Category
Article
ISSN
0959-9673

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Heparan sulfate proteoglycans (HSPGs) are ubiquitous macromolecules associated with the cell surface and extracellular matrix (ECM) of a wide range of cells of vertebrate and invertebrate tissues [1,2]. The basic HSPG structure consists of a protein core to which several linear heparan sulfate (HS)