Molecular Pathology in Clinical Practice || Hereditary Nonpolyposis Colorectal Cancer
โ Scribed by Leonard, Debra G. B.; Bagg, Adam; Caliendo, Angela M.; Kaul, Karen L.; Van Deerlin, Vivianna M.
- Book ID
- 121468141
- Publisher
- Springer New York
- Year
- 2007
- Tongue
- English
- Weight
- 409 KB
- Edition
- 2
- Category
- Article
- ISBN
- 0387332278
No coin nor oath required. For personal study only.
โฆ Synopsis
This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.
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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may
The clinical manifestations of 1,042 Japanese patients with nonpolyposis colorectal cancer who underwent a resection between 1972 and 1992 at the National Kyushu Cancer Center were examined. Hereditary nonpolyposis colorectal cancer (HNPCC) was found in 39 (3.7%) patients. Some characteristic findin