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Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours

✍ Scribed by Fergal C Kelleher; David M Thomas


Book ID
115028013
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
272 KB
Volume
2
Category
Article
ISSN
2045-3329

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EWS-FLI-1 and EWS-ERG chimeric mRNAs in
✍ Kohmei Ida; Shigetoshi Kobayashi; Tomohiko Taki; Ryoji Hanada; Fumio Bessho; Shu πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 620 KB

The t( I I ;22)(q24;q 12) and t(2 I ;22)(q22;q 12) are specific chromosomal translocations found in the Ewing family of tumors including ES, PNET and Askin tumors. In these translocations, the amino-terminal portion of the EWS gene located in 22q12 fuses to the carboxyl-terminal portion of the FLI-I