The Ewing's sarcoma family of tumors are malignant tumors of bone and soft tissue which occur predominantely in children and adolescents. Whereas cure rates for patients with localized tumors are around 70%, survival rates for patients with metastases or relapse are poor in spite of intensive chemo-
✦ LIBER ✦
The Potential for molecular therapeutic targets in Ewing’s sarcoma
✍ Scribed by Nancy R. McAllister; Stephen L. Lessnick
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 791 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1527-2729
No coin nor oath required. For personal study only.
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## Abstract The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI‐1 chimeric fusion protein. The effect of EWS/FLI‐1 appears to be dominant negative since over‐expression of EWS does not overcome the sarcoma phenotype. Pr
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