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Molecular Organization of Protein–DNA Complexes for Cell-Targeted DNA Delivery

✍ Scribed by Anna Arı́s; Antonio Villaverde

Book ID
115586904
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
301 KB
Volume
278
Category
Article
ISSN
0006-291X

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Background Ef®cient and target-speci®c in vivo gene delivery is a major challenge in gene therapy. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles such as anatomical size constraints, interactions with biological ¯uids and extracellular matrix, and