A multi-domain protein for β1 integrin-targeted DNA delivery
✍ Scribed by Fortunati, E; Ehlert, E; van Loo, N-D; Wyman, C; Eble, J A; Grosveld, F; Scholte, B J
- Book ID
- 110038747
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 670 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0969-7128
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A recombinant, multifunctional protein has been designed for optimized, cell-targeted DNA delivery and gene expression in mammalian cells. This hybrid construct comprises a viral peptide ligand for integrin ␣ V  3 binding, a DNA-condensing poly-L-lysine domain, and a complete, functional -galactos
## Abstract Serine/threonine protein phosphatase (PP) 2A is thought to dephosphorylate phosphorylated β1 integrin to link with actin filaments (F‐actin). However, whether PP2A participates in the regulation of F‐actin assembly to which β1 integrin is anchored is unclear. We report here that the cor