While patients with type 2B von Willebrand's disease often exhibit thrombocytopenia, platelet morphology is typically normal. We describe a 44-year-old Jamaican man with thrombocytopenia and a history of bleeding, who had giant platelets on his peripheral blood film. Functional studies and von Wille
Molecular misdiagnosis in type 2B von Willebrand disease
β Scribed by Sebastien Schmitt; Marc Trossaert; Fabrice Airaud; Gaelle Landeau-Trottier; Patricia Talarmain; Pierre Boisseau; Edith Fressinaud; Stephane Bezieau
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 338 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0361-8609
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DDAVP is effective treatment in most types of von Willebrand's disease; however, in type 28 von Willebrand's disease the use of DDAVP has been contraindicated due to DDAVPinduced thrombocytopenla. Several reports have confirmed the thrombocytopenic effects of DDAVP and the presence of circulating pl
## Abstract P selectin is a component of endothelial WiebelβPalade body membrane and platelet alpha granule membrane. Patients with von Willebrand disease (VWD) have low plasma von Willebrand factor (VWF). To examine the relationship between plasma P selectin and VWF, both were measured by ELISA in
Type 2B von Willebrand's disease (VWD) is due to a qualitative defect in von Willebrand factor (VWF) in which there is an increased affinity for the platelet glycoprotein Ib-IX-V receptor complex. Spontaneous binding of type 2B VWF to platelets and subsequent clearance from the plasma is thought to