Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease
✍ Scribed by A.D. Blann; I.C. Nitu-Whalley; C.A. Lee; G.Y.H. Lip
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 52 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Abstract
P selectin is a component of endothelial Wiebel‐Palade body membrane and platelet alpha granule membrane. Patients with von Willebrand disease (VWD) have low plasma von Willebrand factor (VWF). To examine the relationship between plasma P selectin and VWF, both were measured by ELISA in 38 patients with VWD and 40 controls. The patient had lower VWF (P < 0.001) but similar P selectin levels (P = 0.458). In 24 type 1 VWD patients, VWF and P selectin correlated inversely (P = 0.005) but in 14 type 2 VWD patients there was no correlation (P = 0.997). These data imply major differences in VWF/P‐selectin regulation between types 1 and 2 VWD. Am. J. Hematol. 69:135–137, 2002.© 2002 Wiley‐Liss, Inc.