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Molecular mechanisms underlying deregulation of C/EBPα in acute myeloid leukemia

✍ Scribed by Kristian Reckzeh; Jörg Cammenga

Book ID
107619024
Publisher
Carden Jennings Publishing
Year
2010
Tongue
English
Weight
430 KB
Volume
91
Category
Article
ISSN
0925-5710

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A family harboring a germ-line N-terminal C/EBPα mutation and development of acute myeloid leukemia with an additional somatic C-terminal C/EBPα mutation
✍ Tomoko Nanri; Naokuni Uike; Toshiro Kawakita; Eisaku Iwanaga; Hiroaki Mitsuya; N 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

## Abstract C/EBPα plays an essential role as a transcription factor in myeloid cell differentiation. Here, we describe a Japanese family in which two individuals with acute myeloid leukemia (AML) and one healthy individual had an identical 4‐base pair insertion in the N‐terminal region of __CEBPA_