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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

✍ Scribed by Pabst, Thomas; Mueller, Beatrice U.; Zhang, Pu; Radomska, Hanna S.; Narravula, Sailaja; Schnittger, Susanne; Behre, Gerhard; Hiddemann, Wolfgang; Tenen, Daniel G.

Book ID
109830141
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
708 KB
Volume
27
Category
Article
ISSN
1061-4036

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## Abstract A myeloid leukemia cell line designated Kasumi‐6 was established from the bone marrow cells of an individual with acute myeloid leukemia, subtype M2. Both the original leukemic cells and the Kasumi‐6 cell line harbor a hemizygous point mutation in the gene encoding the CCAAT/enhancer bi