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Molecular mechanisms of membrane transport of vitamin E

✍ Scribed by Tappei Takada; Hiroshi Suzuki


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
281 KB
Volume
54
Category
Article
ISSN
1613-4125

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✦ Synopsis


Abstract

Vitamin E is an essential fat‐soluble micronutrient for higher mammals and functions as an antioxidant for lipids and also as a regulator of gene expression and a modulator of cell signaling and proliferation. To exert its physiological functions, vitamin E must achieve an appropriate disposition throughout the body via several processes, such as intestinal absorption, uptake and efflux in peripheral tissues and biliary secretion. In this review, we mainly discuss membrane proteins involved in these transport processes (ATP‐binding cassette transporter A1, scavenger receptor class B type I, Niemann‐Pick C1‐like 1 and multidrug resistance 3) and vitamin E‐mediated regulation of their expression.


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