Molecular mechanisms of membrane transport of vitamin E
β Scribed by Tappei Takada; Hiroshi Suzuki
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 281 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1613-4125
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β¦ Synopsis
Abstract
Vitamin E is an essential fatβsoluble micronutrient for higher mammals and functions as an antioxidant for lipids and also as a regulator of gene expression and a modulator of cell signaling and proliferation. To exert its physiological functions, vitamin E must achieve an appropriate disposition throughout the body via several processes, such as intestinal absorption, uptake and efflux in peripheral tissues and biliary secretion. In this review, we mainly discuss membrane proteins involved in these transport processes (ATPβbinding cassette transporter A1, scavenger receptor class B type I, NiemannβPick C1βlike 1 and multidrug resistance 3) and vitamin Eβmediated regulation of their expression.
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