Antioxidation property of vitamin E-coated polysulfone dialysis membrane and recovery of oxidized vitamin E by vitamin C treatment

✍ Scribed by Ken-ichiro Yamamoto; Masato Matsuda; Masashi Okuoka; Taiji Yakushiji; Makoto Fukuda; Takehiro Miyasaka; Yutaka Matsumoto; Kiyotaka Sakai

• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 273 KB
• Volume: 302
• Category: Article
• ISSN: 0376-7388
• DOI: 10.1016/j.memsci.2007.06.038

✦ Synopsis

The antioxidation property of vitamin E-coated dialysis membrane is effective for reduction of oxidative stress. Effect of amount of vitamin E coating on antioxidation property has been poorly understood yet. In the present study, we evaluated a relationship between amount of vitamin E coating and antioxidation property using a superoxide probe of 2-methyl-6-p-methoxyphenylethynylimidazopyrazinone (MPEC) by the optical fiber method to determine optimum amount of vitamin E coating and to improve antioxidation property of the vitamin E-coated dialysis membrane. Furthermore, from the viewpoint of reuse, we examined recovery of oxidized vitamin E by vitamin C treatment. In conclusion, it is necessary to coat polysulfone dialysis membranes with vitamin E at over 74 mg/m 2 . The antioxidation property is recoverable by treating dialysis membrane containing oxidized vitamin E with vitamin C. By administrating vitamin C, higher antioxidation property may be realized with a small amount of vitamin E coating.