Molecular Mechanisms of Antisense Drugs: RNase H
β Scribed by CROOKE, STANLEY T.
- Book ID
- 120471765
- Publisher
- Mary Ann Liebert
- Year
- 1998
- Tongue
- English
- Weight
- 227 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1087-2906
No coin nor oath required. For personal study only.
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The different extent of the target RNA cleavage at t 99.9% by RNase H in the AON-RNA duplexes, at the RNA saturation condition by antisense oligo, is due to different recognition and catalytic properties of RNase H toward the hybrids owing to different substituents at the 3%-end of the AONs, not owi