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Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

✍ Scribed by Christophe Denoyelle; Patricia Albanese; Georges Uzan; Li Hong; Jean-Pierre Vannier; Jeannette Soria; Claudine Soria


Book ID
114283780
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
451 KB
Volume
15
Category
Article
ISSN
0898-6568

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3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, a precursor of cholesterol that is also required for cell proliferation. Mevalonate depletion results in a G1 phase cell cycle arrest that is mediated in part by impaired activity of cyclin-dependent kin