Molecular mechanics and 1H NMR conformational study of 3,8-diazabicyclo[3,2,1] octanes and related cis-2,6-dimethylpiperazines active on opioid receptors
β Scribed by Lucio Toma; Giorgio Cignarella; Daniela Barlocco; Fiamma Ronchetti
- Book ID
- 119482486
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 452 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0040-4020
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A series of trimethyipiperazine derivatives, structurally related to the Ix-agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane, have been synthesized and teswxl in binding studies, using 3H-DAMGO as Ix-selective ligand. Their different affinity towards Ix-opioid receptors has been interpre
Trimethylpiperazines as Monocyclic Analogues of the . mu.-Opioid Agonist 3,8-Diazabicyclo(3.2.1)octanes: Synthesis, Modeling, and Activity. -The trimethylpiperazine derivatives (IV)-(VII) are tested in binding studies for Β΅-opioid receptors. Their different affinity towards . mu.-opioid receptors i
## Abstract The ^1^H and ^13^C NMR spectra of 2,4,6,8βtetraarylβ3,7βdiazabicyclo[3.3.1]nonanβ9βones (1β2), oximes (3β8) and __O__βbenzyl oximes (9β12) were recorded. The chemical shifts were unambiguously assigned using 1D and 2D NMR spectral data. The results clearly indicate that the compounds ex