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Molecular mapping of the putative gonadoblastoma locus on the Y chromosome

✍ Scribed by Pia Salo; Helena Kääriäinen; Vida Petrovic; Päivi Peltomäki; David C. Page; Albert de la Chapelle

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
412 KB
Volume
14
Category
Article
ISSN
1045-2257

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✦ Synopsis

Based on the high incidence of gonadoblastoma in females with X Y gonadal dysgenesis or 45,X/46,XY mosaicism, the existence of a susceptibility locus on the Y chromosome (GBY) has been postulated. We attempted to map GBY by making use of a recently developed dense map of Y-chromosomal sequence-tagged sites (STSs). In two female patients with gonadoblastoma, small marker chromosomes contained portions of the Y chromosome, and a single region of overlap could be defined extending from probe pDP97 in interval 4B, which contains the centromere, to marker SY I82 in interval 5E of the proximal long arm. This interval is contained in a YAC contig that comprises approximately 4 Mb of DNA. Our findings confirm the previous localization of GBY and greatly refine it. The localization of GBY overlaps with the region to which a putative growth determinant, GCY, was recently assigned. Genes Chromosom Cancer 142 10-214 (1995).

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