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Molecular identification of individuals at high risk for lung cancer

✍ Scribed by John F. Lechner; Robin E. Neft; Frank D. Gilliland; Richard E. Crowell; Steven A. Belinsky

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 66 KB
Volume: 5
Category: Article
ISSN: 1065-7541
DOI: 10.1002/(sici)1520-6823(1997)5:3<103::aid-roi3>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

The objective of the work reviewed herein was to evaluate whether a cancerization field-consisting of cells with genetic alterations can be detected within normal-appearing bronchial epithelium. By using fluorescence in situ hybridization (FISH) for trisomy 7, cancerization fields were detected in the majority of cancer patients and also in significant percentages of cancer-free tobacco smokers and former uranium miners. These results suggest that molecular analyses may enhance the power of detecting premalignant changes in bronchial epithelium and may ultimately lead to identifying persons at greatest risk for developing lung cancer.

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