Frequent allelic loss at chromosome 3p d
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Hélène Blons; J. Pablo Radicella; Ollivier Laccourreye; Daniel Brasnu; Philippe
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Article
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1999
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John Wiley and Sons
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English
β 170 KB
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Cigarette smoking is the major known risk factor for head and neck cancer. Tobacco promotes oxidative stress and enhances tissue levels of 8-hydroxyguanine (8-OH-G) in smokers. The presence of 8-OH-G does not impede replication but leads to an accumulation of G 3 T transversions. Recently, the gene