Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase
✍ Scribed by Jean-Christophe Amé; Elaine L. Jacobson; Elaine L. Jacobson; Elaine L. Jacobson; Myron K. Jacobson; Myron K. Jacobson
- Book ID
- 110242960
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 66 KB
- Volume
- 193
- Category
- Article
- ISSN
- 0300-8177
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## Contents Poly(ADP‐ribose) glycohydrolase (PARG) is the enzyme which degrades poly(ADP‐ribose) polymers synthesized by poly(ADP‐ribose) polymerase (PARP). Both enzymes are activated in response to different stimuli like oxidative stress and are involved in DNA repair processes. The retention of b
A number of roles have been ascribed to poly(ADPribose) polymerase\* including involvement in DNA repair, cell proliferation, differentiation and transformation. Cloning of the gene has allowed the development of molecular biological approaches to elucidate the structure and the function(s) of this