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Molecular genetics of complex I-deficient Chinese hamster cell lines

โœ Scribed by Immo E. Scheffler; Nagendra Yadava; Prasanth Potluri

Book ID
119193038
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
273 KB
Volume
1659
Category
Article
ISSN
0005-2728

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A class of purine auxotrophs blocked early in the purine biosynthetic pathway was examined. The inability of these mutants to accumulate formylglycinamide ribotide (FGAR) in the presence of azaserine suggested that one or more of the first three enzymes of the pathway were either missing or defectiv