Molecular genetics of colorectal carcinoma
โ Scribed by Stanley R. Hamilton
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 612 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh
Abbreviations: DCC, deleted in colon cancer (gene); MCC, mutated in colon cancer (gene); APC, adenomatous polyposis coli (gene); PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; SSCP, single strand conformation polymorphism; ICC, immunocytochemistry; LOH, loss of heter
## BACKGROUND. The hereditary nonpolyposis colorectal carcinoma (HNPCC) syndrome is an autosomal dominant genetic disorder caused by the inheritance of a mutation in one of a family of genes encoding DNA mismatch repair (MMR) proteins. HNPCC manifests as genetic instability in linked tumors. Clini