Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma and molecular genetics of colorectal carcinoma
โ Scribed by Stanley R. Hamilton; Scott E. Kern
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 94 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
with the germline mutation of a DNA mismatch repair gene. Tumors from these Departments of Pathology and Medicine, Copatients typically exhibit microsatellite instability, which is a reflection of their lumbia University College of Physicians & Surlack of mismatch repair activity. The genetic diagno
For about a decade, the model proposed by Fearon and Vogelstein has been the paradigm of the genetic alterations involved in the development of colorectal carcinoma. During this time, much information has become available on the function of the key genes in this model, as well as on their interactio
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh
## Background and objectives: The transitional zone, which is normal-appearing mucosa that surrounds a primary colorectal carcinoma, has characteristic histologic features, and an increased amount of sialomucin in the transitional zone have been associated with a poorer prognosis. to clarify the pr