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Molecular genetics in acute and chronic leukemias

✍ Scribed by Thomas Burmeister; Eckhard Thiel


Book ID
106124544
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
143 KB
Volume
127
Category
Article
ISSN
1432-1335

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The chromosome breakpoints of the acute promyelocytic leukemia (APL)-specific 15;17 translocation have recently been isolated. They are localized on a previously unknown gene, PML, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (RART) on 17. The translocation, which i