Molecular genetic analysis of theREST/NRSFgene in nervous system tumors
β Scribed by Tea Blom; Olli Tynninen; Marjut Puputti; Maija Halonen; Anders Paetau; Hannu Haapasalo; Minna Tanner; Nina N. Nupponen
- Book ID
- 106073409
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 422 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0001-6322
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
W e previously reported the non-random occurrence of rnonosomy 22 in rhabdoid or atypical teratoid tumors of the brain in three young children. W e now present cytogenetic and molecular studies of an additional rhabdoid tumor with the karyotype 46,XX. -9, -22. t i( Iq), + der(22)t(9;22)(p I3;q I 1)/
## Abstract The clonal loss of genetic information as revealed by the comparison of normal and tumor DNA restriction fragment length alleles has permitted the determination of the genomic positions of cancerβrecessive mutations. Here we have applied this approach to the analysis of 19 central nervo
Deletion of 17p is the most frequent abnormality observed in central nervous system (CNS) primitive neuroectodermal tumors (PNETs), implicating the presence of a tumor suppressor gene which maps to 17p. The gene for pigment epitheliumderived factor (PEDF) has been cloned and mapped to 17p13. PEDF be