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Molecular analysis of a partial deletion of 22q in a central nervous system rhabdoid tumor

✍ Scribed by Dr. Jaclyn A. Biegel; Carol D. Burk; Annette H. Parmiter; Beverly S. Emanuel

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
474 KB
Volume
5
Category
Article
ISSN
1045-2257

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✦ Synopsis

W e previously reported the non-random occurrence of rnonosomy 22 in rhabdoid or atypical teratoid tumors of the brain in three young children. W e now present cytogenetic and molecular studies of an additional rhabdoid tumor with the karyotype 46,XX. -9, -22. t i( Iq), + der(22)t(9;22)(p I3;q I 1)/45,XX, -9, -10, -22, + i( Iq), + der(22)t(9;22)(p I3;q I I). These studies further demonstrate the involvement of chromosome 22, and they begin to define the critical region containing a gene or genes involved in the development or progression of rhabdoid tumors of the brain. Genes Chrorn Cancer 5: 104-1 08 ( I 992). 1992 Wiley-Liss. Inc.

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