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Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone

✍ Scribed by Ronald M. Adkins; John Vandeberg; Wen-Hsiung Li


Book ID
117519753
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
378 KB
Volume
246
Category
Article
ISSN
0378-1119

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Binding of growth hormone (GH) to its receptor (GHR) is a well-studied example of molecular recognition between a cytokine and its receptor. Extensive mutagenesis studies and several crystal structures have defined the key interactive amino acid residues that are involved in binding and subsequent r