✦ LIBER ✦

Molecular recognition events involved in the activation of the growth hormone receptor by growth hormone

✍ Scribed by Stuart N. Behncken; Michael J. Waters

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 981 KB
Volume: 12
Category: Article
ISSN: 0952-3499
DOI: 10.1002/(sici)1099-1352(199911/12)12:6<355::aid-jmr477>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

Binding of growth hormone (GH) to its receptor (GHR) is a well-studied example of molecular recognition between a cytokine and its receptor. Extensive mutagenesis studies and several crystal structures have defined the key interactive amino acid residues that are involved in binding and subsequent receptor dimerization. This review encompasses each of the three molecular recognition events involved in GHR activation, namely binding of GH to its two receptors and the interactions that occur between these receptors. Particular attention is given to species and ligand specificity of hormone binding and to the molecular recognition events involved in receptor activation, including the possibility that a conformational change in the receptor is required.

📜 SIMILAR VOLUMES

The calcium-mediated promotion of mitoti

The calcium-mediated promotion of mitotic activity in rat thymocyte populations by growth hormone, neurohormones, parathyroid hormone and prolactin

✍ J. F. Whitfield; A. D. Perris; T. Youdale 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 725 KB

Developmental changes in the expression

Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish

✍ Sandra L. Krueckl; Erica A. Fradinger; Nancy M. Sherwood 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 791 KB

The importance of hormone receptor analy

The importance of hormone receptor analysis in osteosarcoma cells growth submitted to treatment with estrogen in association with thyroid hormone

✍ Patricia Pinto Saraiva; Silvania Silva Teixeira; Sandro José Conde; Célia Regina 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB

Haplotype analysis of the growth hormone

Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor

✍ Wajnrajch, Michael P. ;Gertner, Joseph M. ;Sokoloff, Alisa S. ;Ten, Irina ;Harbi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB 👁 2 views

Molecular diagnosis of deletions in the

Molecular diagnosis of deletions in the human multigene complex of growth and placental lactogen hormones

✍ González-Rodríguez, E.; Jaramillo-Rangel, G.; Barrera-Saldaña, H. A. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB 👁 2 views

The type IA of the isolated deficiencies (ID) of growth (HGH) and placental lactogen (HPL) hormones are frequently the consequence of deletions in their respective genes. To facilitate the diagnosis of these cases, we developed a rapid method for detecting deletions of the genes involved based on th

Properties of growth hormone receptors i

Properties of growth hormone receptors in relation to the adipose conversion of 3T3 cells

✍ Tracy Nixon; Howard Green 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 624 KB

## Abstract Cultured preadipose 3T3 cells undergo a process of differentiation in which they convert to adipose cells. Growth hormone promotes this conversion. Since 3T3 sublines vary in their susceptibility to adipose conversion, it was of interest to examine the properties of the growth hormone r