Molecular evidence that the hepatitis C virus replicates in the oral mucosa
β Scribed by Marco Carrozzo; Rafael Quadri; Patrizia Latorre; Monica Pentenero; Simona Paganin; Giorgio Bertolusso; Sergio Gandolfo; Francesco Negro
- Book ID
- 118564724
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 103 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0168-8278
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GB virus-C and the hepatitis G virus (GBV-C/ HGV) are variants of the same positive sense RNA flavivirus, initially thought to be associated with hepatitis. The tissue tropism of GBV-C/HGV in normal subjects has not been evaluated to date using an extended tissue spectrum. Therefore, the sites of GB
## Abstract Hepatitis C virus (HCV) is the major causative agent of bloodβborne hepatitis. The majority of HCVβinfected individuals develop chronic hepatitis, which eventually progresses to liver cirrhosis, and hepatocellular carcinoma. Although the precise mechanisms of entry, replication, assembl
together at a relatively high density. In natural infec-SEE ARTICLE ON PAGE 205. tions, the presence of HCV 6 in macrophages [7][8][9] and Kupffer cells 10 suggests that Fc receptors, which bind In this issue of HEPATOLOGY, Shimizu et al. 1 build to a conserved portion of antibodies, may facilitate