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Molecular electrostatic potential as a factor of drug–receptor recognition

✍ Scribed by Felix S. Dukhovich; Michael B. Darkhovskii

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
711 KB
Volume
16
Category
Article
ISSN
0952-3499

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✦ Synopsis

Abstract

When a drug molecule approaches a non‐specific acceptor both molecules are in electrostatic fields of equal sign which prevents drug–acceptor complex formation. At the same time, the drug–acceptor system does not achieve the thermodynamic global minimum. Otherwise, when a certain drug interacts with its specific receptor, mutual compensation of their molecular electrostatic potentials takes place. Then separate atoms and groups of the drug molecule can bind to the receptor. We show that the fundamental role of molecular electrostatic potential in the process of drug–receptor recognition consists in fast correction of errors. Copyright © 2003 John Wiley & Sons, Ltd.

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