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Molecular Dynamics Study of the Connection between Flap Closing and Binding of Fullerene-Based Inhibitors of the HIV-1 Protease†

✍ Scribed by Zhu, Zhongwei; Schuster, David I.; Tuckerman, Mark E.


Book ID
115476505
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
156 KB
Volume
42
Category
Article
ISSN
0006-2960

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## Abstract The constants of binding of five peptide analogs to the active site of the HIV‐1 aspartic‐protease are calculated based on a novel sampling scheme that is efficient and does not introduce any approximations in addition to the energy function used to describe the system. The results agre