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Identifying the Molecular Mechanics and Binding Dynamics Characteristics of Potent Inhibitors to HIV-1 Protease

✍ Scribed by Dechang Li; Ming S. Liu; Baohua Ji; Keh-Chih Hwang; Yonggang Huang


Book ID
114854042
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
792 KB
Volume
80
Category
Article
ISSN
1747-0277

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## Abstract The constants of binding of five peptide analogs to the active site of the HIV‐1 aspartic‐protease are calculated based on a novel sampling scheme that is efficient and does not introduce any approximations in addition to the energy function used to describe the system. The results agre