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Molecular Dynamics Simulations of p53 DNA-Binding Domain

✍ Scribed by Lu, Qiang; Tan, Yu-Hong; Luo, Ray

Book ID
120060825
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
339 KB
Volume
111
Category
Article
ISSN
0022-3654

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✍ L. M. Espinoza-Fonseca; JosΓ© G. Trujillo-Ferrara πŸ“‚ Article πŸ“… 2006 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 310 KB

## Abstract Two 35‐ns molecular dynamics simulations of both ligated [mouse double minute protein 2 (MDM2^p53^)] and unligated (MDM2^apo^) structures of human MDM2 bound to the N‐terminal domain of the tumor suppressor p53 have been performed. Analysis of the dynamics revealed that the most flexibl