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Dimerization of the p53 Oligomerization Domain: Identification of a Folding Nucleus by Molecular Dynamics Simulations

✍ Scribed by Lillian T. Chong; Christopher D. Snow; Young Min Rhee; Vijay S. Pande


Book ID
116661799
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
859 KB
Volume
345
Category
Article
ISSN
0022-2836

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## Abstract Two 35‐ns molecular dynamics simulations of both ligated [mouse double minute protein 2 (MDM2^p53^)] and unligated (MDM2^apo^) structures of human MDM2 bound to the N‐terminal domain of the tumor suppressor p53 have been performed. Analysis of the dynamics revealed that the most flexibl