Previous simulations of aqueous solutions of immobilized pairs of simple hydrophilic or hydrophobic model solutes have been extended to consider a mixed hydrophobic-hydrophilic pair. Results show that the replacement of a hydrophilic group with a hydrophobic group can induce relevant changes in the
Molecular dynamics simulation ofα-melanocyte stimulating hormone in a water-membrane model interface
✍ Scribed by Pedro Geraldo Pascutti; Lea Jaccoud El-Jaik; Paulo Mascarello Bisch; Kleber Carlos Mundim; Amando Siuiti Ito
- Book ID
- 105947140
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 541 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1432-1017
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## Abstract ## Objective Recently, we found that human dermal fibroblasts (HDFs) express melanocortin 1 receptors (MC‐1R) that bind α‐melanocyte–stimulating hormone (α‐MSH). In search of novel therapies for scleroderma (systemic sclerosis [SSc]), we used the bleomycin (BLM) model to investigate th