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Molecular Diversity of HLA-DQ

✍ Scribed by Ronald E. Bontrop; Erik J. Baas; Nel Otting; Geziena M. T. Schreuder; Marius J. Giphart

Book ID
118287639
Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
842 KB
Volume
25
Category
Article
ISSN
0093-7711

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At the Ninth International Histocompatibility Workshop (Munich, 1984), DP, DQ, and DR antigens were officially recognized as the class II gene products of the HLA complex (Bodmer et al. 1984). The DP, DQ, and DR loci were considered to have at least 6, 3, and 14 (2 more in a proximal locus) alleles,

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The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic an