𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular Design and Chemical Synthesis of a Highly Potent Epothilone.

✍ Scribed by K. C. Nicolaou; Benjamin A. Pratt; Stellios Arseniyadis; Markus Wartmann; Aurora O'Brate; Paraskevi Giannakakou

Publisher
John Wiley and Sons
Year
2006
Weight
12 KB
Volume
37
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Rational Design and Synthesis of Highly
Rational Design and Synthesis of Highly Potent Ξ²-Glucocerebrosidase Inhibitors
✍ Xiaoxiang Zhu; Kamlesh A. Sheth; Shihong Li; Hui-Hwa Chang; Jian-Qiang Fan πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 114 KB πŸ‘ 1 views

Scheme 1. Synthesis of IFG (1) and IFG derivatives 2-8. a) CH 2 = C(OMe)Me, TsOHβ€’H 2 O, THF, 1.5 h, 0 8C (53 %); b) Tf 2 O, pyridine, CH 2 Cl 2 , 2 h, Γ€78!0 8C; then KCN, 18[crown]-6, DMF, 16 h, RT (80 %); c) RMgX, Et 2 O, 2 h, RT; then NaBH 4 , overnight, RT (65-74 %); d) H 2 , 20 % Pd(OH) 2 /C, Ac