## Abstract The field of molecular cytogenetics has had a great impact on many aspects of medical and basic sciences. During the past 30 years, the application of molecular cytogenetic methodologies has resulted in remarkable advances in the field of cancer genetics and cytogenetics. These advances
Molecular cytogenetics of childhood hematological malignancies
β Scribed by Martinez-Climent, J A
- Book ID
- 110053676
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 257 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The present study was undertaken to ascertain the frequency of cytogenetic polyclonality in various hematologic malignancies and to investigate whether morphologic subgroup, age, gender, or previous genotoxic exposure influences the incidence. Among 2,243 cytogenetically investigated hematologic mal
Most hematopoietic malignancies are widely disseminated even in their "early" stages and often do not have a well-defined localized phase. This makes them less amenable to conventional early screening methods such as imaging and observation. Furthermore, the staging systems for lymphomas are not par
Childhood leukemia is the commonest form of childhood cancer and represents clonal proliferation of transformed hemopoietic cells as a result of genetic changes. Molecular characterization of these changes, in particular chromosomal translocations, has yielded a wealth of information on the mechanis
The Wilms' tumor gene WT1, whose loss of function accounts for the genesis of about 10% of Wilms' tumors, is expressed in hematopoietic stem cells and leukemia. By analogy with the relationship between the kidney stem cell and Wilms' tumor, it is probable that WT1 is mutated in leukemia. WT1 mutatio