Molecular cytogenetic characterization of desmoid tumors
✍ Scribed by Petter Brandal; Francesca Micci; Bodil Bjerkehagen; Mette Eknæs; Marcelo Larramendy; Ragnhild A Lothe; Sakari Knuutila; Sverre Heim
- Book ID
- 114135637
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 202 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The clinical ciiurse ot bladder cancer i s not predicted by histological criteria alone. Mutation dt p53, usually accompanied by allelic loss on the other chromosome 17p, lids been implicated as a prohmostic parameter in several tumors, including hladder cancer. We therefore examined 153 bladder can
## Abstract Desmoid tumors are fibroblastic/myofibroblastic proliferations. Previous studies reported that __CTNNB1__ mutations were detected in 84% and that mutations of the __APC__ gene were found in several cases of sporadic desmoid tumors lacking __CTNNB1__ mutations. Forty tumors were analyzed
Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on Short-term cultures and frozen sections. Trisomy 8 was detected in four out of ten tumors, of which only one had shown t r i m y 8 by karyotype analysis. Since trisomy 8 has been reported in superficial f