Molecular cytogenetic analysis of clustered sporadic and familial renal cell carcinoma-associated 3q13∼q22 breakpoints
✍ Scribed by Daniëlle Bodmer; Irene Janssen; Yvonne Jonkers; Eva van den Berg; Trijnie Dijkhuizen; Maria Debiec-Rychter; Eric Schoenmakers; Ad Geurts van Kessel
- Book ID
- 114135328
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 186 KB
- Volume
- 136
- Category
- Article
- ISSN
- 0165-4608
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## Abstract We identified a novel familial case of clear‐cell renal cancer and a t(3;6)(q12;q15). Subsequent cytogenetic and molecular analyses showed the presence of several abnormalities within tumour samples obtained from different patients. Loss of the der(3) chromosome was noted in some, but n
On a genetic level, renal-cell carcinoma has been characterized by an abnormality on the short arm of chromosome 3 (3p), which suggests the inactivation of a tumor suppressor gene. One tumor suppressor gene at 3p, the von Hippel-Lindau disease gene, is implicated in tumor development of a whole spec