## Abstract The inner ear, which mediates hearing and equilibrium, develops from an ectodermal placode located adjacent to the developing hindbrain. Induction of the placode and its subsequent morphogenesis and differentiation into the inner ear epithelium and its sensory neurons, involves signalli
Molecular cloning and developmental expression of rat fibroblast growth factor receptor
β Scribed by Peter Claus; Claudia Grothe
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 516 KB
- Volume
- 115
- Category
- Article
- ISSN
- 1432-119X
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## Abstract A cDNA clone encoding rat basic fibroblast growth factor (bFGF) was used as a hybridization probe to determine the level of bFGF mRNA during rat brain development as well as in different adult rat brain regions. In the rat brain, a 3.7kb bFGF RUNA was detected together with lower levels
Fibroblast growth factors (FGFs) exert various effects on glial cells as well as on neurons in the brain. The mRNAs for four FGF receptors (FGFR-1-FGFR-4) are expressed in the brain. Although FGFR-1 and -4 mRNAs are preferentially expressed in neurons, FGFR-2 and -3 mRNAs are preferentially expresse