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Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs

✍ Scribed by A. Miyake; Y. Hattori; M. Ohta; N. Itoh

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 792 KB
Volume: 45
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19960901)45:5<534::aid-jnr3>3.0.co;2-d

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✦ Synopsis

Fibroblast growth factors (FGFs) exert various effects on glial cells as well as on neurons in the brain. The mRNAs for four FGF receptors (FGFR-1-FGFR-4) are expressed in the brain. Although FGFR-1 and -4 mRNAs are preferentially expressed in neurons, FGFR-2 and -3 mRNAs are preferentially expressed in glial cells. However, the glial cells that express these receptors remained to be identified. In this study, we found that oligodendrocytes and astrocytes in the brain preferentially expressed FGFR-2 and FGFR-3 rnRNAs, respectively. The isoforms of immunoglobulin-like domain I11 (IIIb and IIIc) of the receptors have crucial roles in ligand binding. We also determined the isoforms of FGFR-2 and FGFR-3 expressed in glial cells to be of type IIIc. The expression of FGFR-2 IIIc and FGFR-3 IIIc with different ligand specificities might play important roles in the various effects of FGFs on oligodendrocytes and aStrOCyteS. 0 1996 Wiiey-Liss, Inc.

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