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Molecular cloning and characterization of the human topoisomerase IIα and IIβ genes: evidence for isoform evolution through gene duplication

✍ Scribed by Jen-Hwei Sng; Victoria J. Heaton; Margaret Bell; Pankaj Maini; Caroline A. Austin; L.Mark Fisher

Book ID
114148486
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
559 KB
Volume
1444
Category
Article
ISSN
0167-4781

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n sylvan la (K. B.T.) DNA was prepared from normal tissue and I9 lung cancer cell lines. Using probes which detect restriction fragment length polymorphisms at both the topoisomerase II u and p loci, heterozygosity was detected at a frequency of 0. I 7 and 0.37 for the