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Molecular cloning and characterization of rat brain 2′, 3′ -cyclic nucleotide 3′ -phosphodiesterase isoform 2

✍ Scribed by M. Gravel; D. DeAngelis; P. E. Braun

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
566 KB
Volume
38
Category
Article
ISSN
0360-4012

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✦ Synopsis

We have isolated a cDNA coding for the larger isoform of the rat brain 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP2), a protein associated with myelination in the central nervous system (CNS). The complete 420 amino acid sequence was deduced from the nucleotide sequence of the cDNA. Sequence comparisons show that rat CNP shares 96% homology with mouse, 84% with bovine, and 86% with human CNP. Errors in the published sequence of rat CNPl have now been corrected. Comparisons with other proteins reveal several interesting conserved motifs, including two leucine repeat heptads, and two consensus motifs for phosphorylation in the N-terminal domain of CNPZ.

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