Molecular Clonality of In-Transit Melanoma Metastasis
β Scribed by Takahiro Nakayama; Bret Taback; Roderick Turner; Donald L. Morton; Dave S.B. Hoon
- Book ID
- 117022022
- Publisher
- American Society for Investigative Pathology
- Year
- 2001
- Tongue
- English
- Weight
- 904 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0002-9440
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The molecular changes associated with the transition of melanoma cells from radial growth phase to vertical growth phase (metastatic phenotype) are not very well defined. Expression of the tyrosine-kinase receptor c-KIT progressively decreases during local tumor growth and invasion of human melanoma
## Abstract Three distinct disseminationβrelated phenotypes have been recognized in clones of the mouse B 16 melanoma based on __in vivo__ behavior: metastatic (spontaneously disseminating to the lungs from solid tumors), colonizing (capable of forming tumor colonies in the lungs following intraven