Colorectal adenomas are macroscopically visible morphological changes of the mucosa that can develop focal carcinoma in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the adenomacarcinoma sequence were primarily based on DNA studies of
Molecular changes in the Ki-ras and APC genes in colorectal adenomas and carcinomas arising in the same patient
β Scribed by N. Peter Zauber; Marlene Sabbath-Solitare; Stephen P. Marotta; Ann G. Zauber; D. Timothy Bishop
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 120 KB
- Volume
- 193
- Category
- Article
- ISSN
- 0022-3417
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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit
In contrast to the origins of colorectal carcinomas, the mechanisms of carcinogenesis in the small intestine remain unclear. We therefore analyzed the mutational status of the Ki-ras, p53, and adenomatous polyposis coli (APC) genes in primary carcinomas of the small intestine and compared the mutati