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Molecular biology of therapy-related leukaemias

✍ Scribed by Melanie Joannides; David Grimwade

Book ID
107597599
Publisher
Springer Milan
Year
2010
Tongue
Spanish
Weight
357 KB
Volume
12
Category
Article
ISSN
1699-048X

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In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, wi