✦ LIBER ✦

Molecular Biology of Human Muscle Disease

✍ Scribed by Dunne, Patrick W. ;Epstein, Henry F.

Book ID: 111963607
Publisher: Nature Publishing Group
Year: 1991
Tongue: English
Weight: 843 KB
Volume: 9
Category: Article
ISSN: 1087-0156
DOI: 10.1038/nbt0191-41

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The amyloid first seen by Alois Alzheimer in the brain of a deceased demented patient (1) turned out to be an extraordinary challenge for biochem ists and molecular biologists alike. The extreme insolubility of this polypeptide first challenged the protein chemists attempting to sequence it (2, 3).